many cancers upregulate an amino acid transporter to fuel their growth, making this protein a promising tool in tumor detection and therapy.
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award-winning care. led by science. rooted in empathy. because every child deserves a future — and every treatment helps create one. right now, we’re building a school in yemen. start your skin journey – and theirs google rated 4.9 diagnostic scans 0 + of profits fund our school in yemen 0 % see what your […]
endometrium is recently introduced as an available source of mesenchymal stem cells (enmscs), which can be obtained without anesthesia and side effects. reg...
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mesenchymal stem cell-derived exosomes: toward cell-free therapeutic strategies in regenerative medicine
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kim m, et al. ann surg treat res. 2024 nov;107(5):252-263. https://doi.org/10.4174/astr.2024.107.5.252
pancreatic cancer, one of the most aggressive tumors, has a dismal prognosis because of the low rates of early identification, fast progression, difficulties following surgery, and the ineffectiveness of current oncologic therapies. there are no imaging techniques or biomarkers that can accurately i …
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medical aesthetics in bradford we specialise in boosting the natural allure of both men and women with non-surgical treatments that help preserve, repair and enhance your appearance. book now endless aesthetics at endless aesthetics, we specialise in advanced aesthetic treatments, led by our clinical pharmacist, naila dad. with a passion for wellness, skincare, and skinceuticals, we are dedicated to providing personalised treatments in a safe and professional environment. our expertise includes dermal fillers, anti-wrinkle treatment, fat dissolving, prp, and prf for both hair and skin rejuvenation. we continuously expand our knowledge and skills in non-surgical aesthetics to ensure the best results for our clients. we believe that everyone deserves to feel beautiful, and our goal is to provide subtle, natural-looking enhancements that leave you feeling confident and radiant. discover more our treatments anti-wrinkle hair loss dermal fillers skin rejuvenation fat dissolving iv drip led light therapy cosmeceuticals check out what our clients say about us why choose us? medically-led treatments – our treatments are performed by naila, our highly skilled medical professional. high-quality products – we use clinically proven, premium products to ensure effective and lasting results. personalised approach – we tailor every treatment to your unique skin and beauty goals for natural-looking results. safe & professional environment – we prioritise safety, hygiene, and the highest standards of care in every procedure. commitment to natural beauty – our focus is on enhancing your features, ensuring subtle, natural-looking enhancements. client-centered care – your comfort, confidence, and satisfaction are at the heart of everything we do. book now
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background leukemic cells facilitate the creation of the tumor-favorable microenvironment in the bone marrow niche using their secreted factors. there are not comprehensive details about immunosuppressive properties of chronic myelogenous leukemia-derived exosomes in the bone marrow stromal and immune compartment. we explained here that k562-derived exosomes could affect the gene expression, cytokine secretion, nitric oxide (no) production, and redox potential of human primary cord blood-derived t cells (cb t cells). methods human primary cord blood-derived t cells were treated with k562-derived exosomes. we evaluated the expression variation of some critical genes activated in suppressor t cells. the alterations of some inflammatory and anti-inflammatory cytokines levels were assessed using elisa assay and real-time pcr. finally, no production and intracellular ros level in cb t cells were evaluated using greiss assay and flow cytometry, respectively. results our results showed the over-expression of the genes involved in inhibitory t cells, including nqo1, pd1, and foxp3. in contrast, genes involved in t cell activation such as cd3d and nfatc3 have been reduced significantly. also, the expression of interleukin 10 (il-10) and interleukin 6 (il-6) mrnas were significantly up-regulated in these cells upon exosome treatment. in addition, secretion of the interleukin 10, interleukin 6, and interleukin 17 (il-17) proteins increased in t cells exposed to k562-derived exosomes. finally, k562-derived exosomes induce significant changes in the no production and intracellular ros levels in cb t cells. conclusions these results demonstrate that k562-derived exosomes stimulate the immunosuppressive properties in cb-derived t cells by inducing anti-inflammatory cytokines such as il-10, reducting ros levels, and arising of no synthesis in these cells. moreover, considering the elevation of foxp3, il-6, and il-17 levels in these cells, exosomes secreted by cml cells may induce the fates of t cells toward tumor favorable t cells instead of conventional activated t cells.
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previous next exosomes this breakthrough treatment is now available at our clinic! exosome therapy is one of the most exciting treatments in the medical and aesthetic world today. rejuvaskin clinic leeds and bradford launched exosome therapy in 2023 and this is as cutting-edge as it gets. exosomes are the signalling messengers from […]
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dermalux led phototherapy in bradford. medically ce certified for acne, psoriasis, skin rejuvenation, hair loss and wound healing. book now multi-award-winning deramlux is a world-leading and trusted brand for professional led phototherapy. its unique groundbreaking led technology is medically certified, clinically proven and backed by science. key benefits of phototherapy: led phototherapy offers several key benefits that make it a popular choice for skin care treatments. the led phototherapy can be used as a standalone therapy or can be combined with other treatments for enhanced results. dermalux, led phototherapy for the face and body, is a non-invasive treatment that gives you visible results which continue to improve after your treatment. skin-enhancing treatments include: skin rejuvenation and anti-ageing – improves collagen and elastin production for healthier and younger-looking skin reduction in acne and blemishes by reducing the growth of bacteria that cause spots and blemishes improves skin tone and texture minimises skin redness and irritation medical benefits of led phototherapy include: acne and acne scarring scar and wound healing rosacea treatment psoriasis hair re-growth treatment inflammatory skin conditions; eczema, rosacea, dermatits pigmentation how does it work? dermalux re-energises your skin cells by using a combination of near-infrared light or wavelengths. this triggers skin cell renewal and repair process promoting collagen and elastin production which are essential for keeping the skin flexible and firm. led phototherapy is clinically proven to encourage collagen and elastin production in the skin to reverse the signs of ageing and improve the texture and overall appearance of the skin leaving it radiant and youthful. watch our dermalux video to find out more about the treatment. https://youtu.be/lmpvmaj4aawthere are three different types of light therapies. during your consultation, our skin expert will talk you through which option will address your skin concerns. each wavelength of light is a different colour, treating various skin conditions at various skin depths. treatment using a single light colour or combination of colours may be recommended by our skin expert. here are the benefits of each light colour: blue light: is antibacterial, calming and treats breakouts red light: boosts collagen production and improves elastin. reduces fine lines and wrinkles and increases hydration. near-infrared light (nir): reduces age spots and pigmentation, calms redness and irritation and is clinically proven to be beneficial. results are seen after one dermalux treatment improving your skin luminosity, hydration and tone. treatment procedure: dermalux therapy has been shown to have mood-enhancing benefits and is a painless, relaxing experience. during the consultation process, our skin expert will thoroughly analyse your skin, address your concerns and recommend a bespoke treatment plan that may be a combination therapy for the desired results. pre-treatment guidelines ensure your skin is clean and free from any makeup, sunscreen or skincare products. remove any jewellery or accessories that may interfere with the led light penetration. avoid excessive sun exposure or tanning beds before treatment, as it can cause increase skin sensitivity. provide information of any changes to your medical history or medication. post-treatment guidelines apply a gentle moisturiser to hydrate the skin post-treatment use a broad-spectrum sunscreen with spf30 or higher to protect the skin from sun damage. avoid harsh skin products or treatments that may irritate the skin for at least 24 hours post-treatment. for optimal results follow the instructions provided by the skin expert. acne and acne scarring treatment dermalux led phototherapy offers advanced, non- invasive solution for acne and acne scarring, promoting clearer, healthier skin. this clinically proven treatment uses wavelengths of light to target acne-causing bacteria ,reduce inflammation, and stimulate cellular repair. benefits of dermalux led phototherapy for acne: reduces active acne: effectively kills bacteria and calms breakouts. minimises scarring: stimulates collagen production to smooth skin texture. promotes skin healing: reduces redness and inflammation for a balanced complexion. safe for all skin types: gentle yet effective, suitable for sensitive skin. the session are pain-free and typically last 20-30minutes. results are noticeable after just a few treatments, with improved skin clarity, reduced redness and minimised scars. for optimal results a course of treatments tailored to your skin’s need wil be recommended during consultation.this can be combined with prp, prf, polynucleotides and exosome. psoriasis treatment psoriasis is a chronic skin condition characterized by inflammation, redness and scaling, often causing discomfort and self- consciousness. dermalux led phototherapy provides an innovative, non-invasive treatment to alleviate psoriasis symptoms and promote healthier skin. benefits of dermalux led phototherapy for psoriasis: reduces inflammation: soothes redness and irritation reducing inflammation. encourages skin repair: stimulates cellular renewal to repair damaged skin. improves skin texture: hydrates and rejuvenates for smoother, healthier skin. safe and gentle: suitable for all skin types, with no downtime. led phototherapy works by the near-infrared light penetrating deep into the skin promoting repair and rejuvenation, whilst the red light targets inflammation and blue light helps eliminate bacteria that may exacerbate psoriasis. book your consultation today for a personalised treatment plan. inflammatory skin treatment living with an inflammatory skin condition such as rosacea, eczema and dermatitis can deeply impact your confidence and comfort, often making even simple daily routines a struggle. the redness, irritation, and flare-ups can feel frustrating and exhausting, leaving you longing for a clearer, calmer skin. at endless aesthetics we understand how these conditions affect not just your skin but your overall well-being. dermalux led phototherapy is a clinically proven treatment, which is safe, non-invasive to calm inflammation, reduce redness and promote skin healing. our tailored treatment plan can help to restore your skin’s balance and help you feel at ease in your own skin. benefits of led phototherapy for inflammatory skin conditions: reduces inflammation: clams irritation and redness with soothing light wavelengths. accelerates healing: stimulates cell repair for faster recovery from flare-ups. enhances skin health: improves hydration and strengthens the skin barriers. suitable for sensitive skin: a gentle, effective option for delicate and reactive skin types. each session lasts 20-30 minutes, providing a relaxing and painless experience. with regular sessions, you’ll notice reduced redness, fewer flare ups and a calmer complexion. pigmentation and skin rejuvenation hyperpigmentation
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functional properties of circulating exosomes mediated by surface-attached plasma proteins
exosomes are endosome-derived small membrane vesicles that are secreted by most cell types including tumor cells. tumor-derived exosomes usually contain tumor antigens and have been used as a source of tumor antigens to stimulate anti-tumor immune responses. however, many reports also suggest that tumor-derived exosomes can facilitate tumor immune evasion through different mechanisms, most of which are antigen-independent. in the present study we used a mouse model of delayed-type hypersensitivity (dth) and demonstrated that local administration of tumor-derived exosomes carrying the model antigen chicken ovalbumin (ova) resulted in the suppression of dth response in an antigen-specific manner. analysis of exosome trafficking demonstrated that following local injection, tumor-derived exosomes were internalized by cd11c+ cells and transported to the draining ln. exosome-mediated dth suppression is associated with increased mrna levels of tgf-β1 and il-4 in the draining ln. the tumor-derived exosomes examined were also found to inhibit dc maturation. taken together, our results suggest a role for tumor-derived exosomes in inducing tumor antigen-specific immunosuppression, possibly by modulating the function of apcs.
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introductionexosomes (exos) as a targeted cell-free therapy could offer a new therapeutic strategy for immune-mediated inflammatory diseases, due to their st...
background multiple sclerosis (ms) is a chronic condition that primarily manifests as demyelination of neuronal axons in the central nervous system, due to the loss or attack of oligodendroglia cells that form myelin. stem cell therapy has shown promising results for the treatment of ms due to its capability to halt the immune attack, stop apoptosis and axonal degeneration, and differentiate into oligodendrocytes. stem cell-derived exosomes (exosomes) have shown great capabilities for neuronal diseases as they have growth factors, complex sets of mirna, enzymes, proteins, major peptides, lipids, and macromolecules with anti-inflammatory, angiogenesis, and neurogenesis activities. methods this study aimed to compare the healing properties of stem cells, against exosomes for the treatment of an experimentally induced ms dog model. dog models of ms received either a single treatment of stem cells or a single treatment of exosomes intrathecally and the treatment process was evaluated clinically, radiologically, histopathologically, and electron microscopy and cerebrospinal fluid analysis. results showed marked amelioration of the clinical signs in both treated groups compared to the control one, magnetic resonance scans showed the resolution of the hyperintense lesions at the end of the study period, the histopathology and electron microscopy showed marked healing properties and remyelination in treated groups with superiority of the stem cells compared to exosomes. conclusions although stem cell results were superior to exosomes therapy; exosomes have proven to be effective and safe important actors in myelin regeneration, and their use in diseases like ms helps to stimulate remyelination.
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europe pmc is an archive of life sciences journal literature.